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Lesson 545 min read

General Biology

Cell Biology, Genetics, and Evolution

Cell Structure

Cell Theory

  1. All living things are made of cells
  2. Cells are the basic unit of life
  3. All cells come from pre-existing cells

Prokaryotic Cells

  • No membrane-bound nucleus
  • No membrane-bound organelles
  • Smaller (1-10 Ξm)
  • Examples: Bacteria, Archaea

Eukaryotic Cells

  • True nucleus with membrane
  • Membrane-bound organelles
  • Larger (10-100 Ξm)
  • Examples: Plants, Animals, Fungi

Key Organelles

Nucleus: Contains DNA, controls cell

Mitochondria: ATP production (powerhouse)

Ribosome: Protein synthesis

ER: Protein (rough) / Lipid (smooth) synthesis

Golgi: Modifies & packages proteins

Lysosome: Digestion & recycling

Chloroplast: Photosynthesis (plants)

Cell Wall: Support (plants, fungi, bacteria)

Cell Division

Mitosis (PMAT)

Division of somatic cells. Results in 2 identical diploid (2n) cells.

Prophase

Chromatin condenses, nuclear envelope breaks

Metaphase

Chromosomes align at cell equator

Anaphase

Sister chromatids separate

Telophase

Nuclear envelope reforms

Meiosis

Division of sex cells. Results in 4 unique haploid (n) cells.

Meiosis I:

  • Homologous pairs separate
  • Crossing over occurs
  • Results in 2 haploid cells

Meiosis II:

  • Similar to mitosis
  • Sister chromatids separate
  • Results in 4 haploid cells

Comparison

FeatureMitosisMeiosis
PurposeGrowth, repairGamete production
Divisions12
Daughter cells2 (2n)4 (n)
Genetic variationNoYes

Genetics

Key Terms

  • Gene: Segment of DNA that codes for a trait
  • Allele: Different versions of a gene
  • Genotype: Genetic makeup (AA, Aa, aa)
  • Phenotype: Physical expression of genes
  • Dominant: Expressed when present (A)
  • Recessive: Only expressed when homozygous (aa)

Mendel's Laws

  • Law of Segregation: Allele pairs separate during gamete formation
  • Law of Independent Assortment: Genes for different traits sort independently

Punnett Square

Tool for predicting offspring genotypes.

Monohybrid cross (Aa × Aa): 25% AA, 50% Aa, 25% aa → 3:1 phenotypic ratio

DNA Structure

  • Double helix structure (Watson & Crick)
  • Sugar-phosphate backbone
  • Nitrogenous bases: A-T, G-C (complementary pairs)
  • DNA → RNA → Protein (Central Dogma)

Evolution

Darwin's Theory of Natural Selection

  1. Variation exists within populations
  2. More offspring are produced than can survive
  3. Individuals with favorable traits survive and reproduce
  4. Favorable traits become more common over time

Evidence for Evolution

  • Fossil record
  • Homologous structures
  • Embryology
  • DNA/molecular evidence
  • Biogeography

Types of Selection

  • Stabilizing: Favors average
  • Directional: Favors one extreme
  • Disruptive: Favors both extremes

Speciation

Formation of new species through reproductive isolation. Can occur through geographic separation (allopatric) or within the same location (sympatric).

Ecology

Levels of Organization

Organism → Population → Community → Ecosystem → Biome → Biosphere

Energy Flow

  • Producers: Make own food (photosynthesis)
  • Consumers: Eat other organisms
  • Decomposers: Break down dead matter
  • Energy decreases ~10% at each trophic level

Biogeochemical Cycles

Carbon: Photosynthesis ↔ Respiration

Nitrogen: Fixation → Nitrification → Denitrification

Water: Evaporation → Condensation → Precipitation

Phosphorus: Rocks → Soil → Organisms

Ecological Relationships

  • Mutualism: Both benefit (+/+)
  • Commensalism: One benefits, other unaffected (+/0)
  • Parasitism: One benefits at expense of other (+/-)
  • Predation: One kills and eats another (+/-)
  • Competition: Both harmed by resource sharing (-/-)

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